Currently full >> << sequence genomes of almost all major bacterial pathogens >> << have been identified. In addition, the genome is
kind, but different species, subspecies, serovars
or patovaru available for most sorts. We begin
appreciate a great diversity of bacterial genomes >> << to virulence-related genes and their organization
. Pathogenic bacteria represent an impressive arsenal of virulence factors >> << that allow they win
many different niches during infection. Especially exciting is the fact that certain bacteria
, in the words of various combinations of virulence factors
, can cause various diseases. Further comparative genome analysis reveals
more interesting information about the biology and evolution
pathogens. Therefore, we recently updated
VFDB, to make it the basis for further comparative study >> << pathogenomics. Key Features
given this version include:
How do I get access to new data comparative pathogenomics:
visit a separate page any agent you're looking for
and follow the link on the page. Or conversely, to visit
comparative data and select agent >> << you are interested Definition: bacterial pathogen, usually defined as >> << any bacteria that could cause disease. Its ability to cause disease is called
pathogenicity. Virulence gives a quantitative measure of pathogenicity
or likelihood of causing disease. Factors related to the virulence properties
(ie, gene products) that allow >> << microorganism to establish itself on the surface or within a range of specific >> << and increase its potential to cause disease. Virulence factors include bacterial toxins, cell surface
proteins that mediate bacterial attachment on the cell surface carbohydrates and proteins >> << that protect bacteria
and hydrolytic enzymes that may contribute to pathogenicity
in bacteria. About VFDB: VFDB is an integrated >> << and comprehensive database of virulence factors for bacterial pathogens
(including chlamydia and mycoplasma). You can visit the
to know the current statistics for entire database >>. << First, to provide comprehensive coverage of major virulence factors
the most characterized bacterial pathogens,
to the structure of features, functions and strattera prescription mechanisms
used by these pathogens to allow them to gain new
niche and bypass a lot of protective mechanisms
and cause disease. Secondly, to provide advanced knowledge of a wide >> << different mechanisms used for bacterial pathogens >> << researchers clarify the pathogenic mechanisms in bacterial diseases
which is not typical and develop new
, rational approaches to treatment and prevention of infectious diseases
. Reference: Chen LH, Xiong ZH, Sun LL, Yang J and Jin Q 2012. VFDB 2012 update: the genetic diversity and molecular evolution of bacterial virulence factors .. [
] [J Yang, Chen LH, LL Su, Yu J and Jin Q 2008. VFDB 2008 issue: expanding Internet resource for comparative pathogenomics .. [
] [Chen LH, Yang J, J Yu Yao ZJ, Sun LL, Shen Jin U and Q, 2005. VFDB: reference database for bacterial virulence factors .. [
] [
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